The PNAC consists of National Government Agencies, such as the Department of Health (DOH), Department of Eduation (DepEd), Department of Labor and Employment (DOLE), Department of Social Welfare and Development (DSWD), Department of the Interior and Local Government (DILG), Civil Service Commission (CSC), Commission on Higher Education (CHED), National Youth Commission (NYC), Philippine Information Agency (PIA), Department of Budget and Management (DBM), Chairperson of the Committee on Health and Demography of the Senate of the Philippines, and Chairperson of the Committee on Health of the House of Representatives. The PNAC also has members coming from the Civil Society Organizations (CSOs), PLHIV communities, private organizations, and Non-Government Organizations.

The PNAC consists of five committees, namely the Information, Education, and Communication Committee, Human Rights Committee, Finance Committee, Monitoring and Evaluation Committee, and Policy and Planning Committee.